Chemistry and Medicines: An Introductory TextRoyal Society of Chemistry, 2006 - 156 עמודים Medicinal chemistry incorporates bio-organic chemistry, organic synthetic methods, physical organic chemistry and organic reaction mechanisms. These areas of chemistry are crucial to the design and synthesis of new drugs, both in academia and the pharmaceutical industry. Chemistry and Medicines: An Introductory Text provides a general introduction to this fascinating subject. The first chapters contain a brief historical introduction followed by a description of the chemical features involved in the adsorption, distribution, metabolism and excretion of a drug. The remaining chapters describe the chemistry underlying the design and synthesis of some of the key drugs used to combat some major diseases of the peripheral and central nervous system, infectious diseases and cancers. A glossary and suggestions for further reading complete this textbook. The book is aimed at those studying advanced undergraduate and postgraduate courses in medicinal chemistry. |
תוכן
Introduction | 1 |
General Principles of Medicinal Chemistry | 20 |
Neurotransmitters as Targets | 41 |
Medicinal Chemistry and the Central Nervous System | 61 |
5 | 72 |
41 | 73 |
Antiinfective Agents | 105 |
Cancer Chemotherapy | 129 |
Further Reading | 142 |
151 | |
מהדורות אחרות - הצג הכל
Chemistry and Medicines: An Introductory Text <span dir=ltr>James R Hanson</span> תצוגה מקדימה מוגבלת - 2007 |
Chemistry and Medicines: An Introductory Text <span dir=ltr>James R Hanson</span> תצוגה מקדימה מוגבלת - 2019 |
מונחים וביטויים נפוצים
acetylcholine action adrenalin adrenergic agonists alkaloid alkyl amino acid anaesthetic analgesic analogues angiotensin antagonists anti-bacterial agents anti-fungal anti-inflammatory antibiotics aromatic ring aspirin associated bacteria binding biological activity biological effect biosynthesis block blood blood:brain barrier brain carbonyl catechol cell wall chapter chemical chlorpromazine cholesterol circulatory system clavulanic acid co-enzyme compounds cross the blood:brain cytochrome P450 dopamine drug enantiomer enzyme enzyme system ester estrogen example excretion formation GABA glands hence histamine hydrolysis hydroxyl infections inflammation inhibition inhibitors interactions involved ion-channels known lead lipid lipophilic liver major medicinal chemistry metabolism metabolite methyl molecule monoamine oxidase morphine muscle nerve nervous system neuroleptic agents neurotransmitters nitrogen noradrenalin nucleic acid nucleophilic organisms oxide paracetamol Parkinson’s disease penicillins peptide phenol pro-drug produced prostaglandins protein re-uptake receptors release role Scheme selective serotonin side chain side effects steric steroid hormones structure substance substituent substrate synthesis target toxic trans-membrane protein treatment viral virus